When God confronted Adam and Eve after their sin in the Garden of Eden, see Genesis 3:1-24, He pronounced a series of curses and punishments; within this God made reference to the coming Christ who was to take away the sin of the world.
“And He said to them, ‘You are from beneath; I am from above. You are of this world; I am not of this world. Therefore I said to you that you will die in your sins; for if you do not believe that I am He, you will die in your sins.’” John 8:23-24.